Tramadol (Ultram) Addiction Treatment

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Tramadol (Ultram) Addiction Treatment

According to the Substance Abuse and Mental Health Services Administration (SAMHSA), the number of ER visits related to tramadol abuse has increased by 250% from 2005 to 2011. Tramadol is another medication in the pool of opioids that treats moderate to severe pain. Although weaker than other prescription and illicit opioids, it can still lead to addiction.

Read on to thoroughly understand the depths of tramadol addiction, its background, how it is abused, and its health risks on human life.

History of Tramadol

The history of tramadol is relatively young compared to other prescription medications. The drug was developed in 1962 by the drug company Grünenthal GmbH that specializes in treating pain. 1 The company was founded in 1946 and has been continuously family-owned. Today, 50% of the company’s revenue is generated by selling pain medications such as tramadol.

Approval and Distribution

After 15 years of testing, the medication was finally approved. It was brought to the foreign market in 1977 under the name Tramal. However, it was not until 1995 that the drug became available in the United States and the United Kingdom.

Prescriptions have increased quickly from 2008 until 2012. During those five years, tramadol prescriptions increased from 23 million in 2008, 28 million in 2010, to more than 37 million in 2012. 2013 saw another increase, with almost 44 million prescriptions in the US alone.

In 2016, with more than 19 million prescriptions, tramadol was the 39th most prescribed medication in the US. 2

Schedule IV Restrictions

In 2014, the Drug Enforcement Administration restricted tramadol. It classified it as a schedule IV drug on the national level. A schedule IV classification means that the medication has:

A medically necessary purpose

Low risk of abuse

Closely monitored and restricted prescriptions and refills. For example, a doctor can only prescribe five refills, patient needs to show a new prescription every six months

A schedule IV classification means more severe punishments for illegal possession, sale, and abuse. If a person is caught possessing the substance, they can be charged with misdemeanor or felony. Some states can even impose a 5-year sentence for having tramadol without a valid prescription.

Other Names

Tramadol is the generic name for the prescription pain reliever. It’s sold under various brand names, including:



Rybix ODT

Ultram ER

Common street names for the drug include:


Chill pills


According to the DEA, there were 3.2 million people over the age of 12 in the US in 2014 who used tramadol for non-medical reasons in their lifetime. This number is around 10% of the total pain reliever abuse market.

Is Tramadol Life-Threatening?

Once, tramadol was believed to have a low risk of abuse, dependence, and addiction. But statistics from recent years are changing the perception people have of the drug. Here’s why:

The emergency room visits due to non-medical use of tramadol have increased from 645 in 1995, 8,029 in 2007, to 20,000 in 2011.

Hospital visits in 1995
Hospital visits in 2007
Hospital visits in 2011

The number of emergency room visits due to adverse reactions to tramadol has also increased. The number grew from 6,207 visits in 2004, 16,946 in 2007, to 25,884 in 2009.

Treatment facility admissions for tramadol addiction have been rising steadily since 2005. In 2002, only 12 people were admitted to a treatment facility, compared to 159 in 2012.

JAMA Study

Another study published in the Journal of the American Medical Association(JAMA) examined the risk of death among 90,000 people one year after they received their first prescription for tramadol or other pain relievers such as naproxen, diclofenac, or codeine. The participants were at least 50 years of age and suffered from osteoarthritis.

The study found that patients who were prescribed tramadol had a higher risk of death than those who were prescribed an anti-inflammatory drug. The numbers were the following:3

2.2% of the patients in the tramadol group died, compared to 1.3% of the patients in the naproxen group.

3.5% of the patients in the tramadol group died, compared to 1.8% of the patients in the diclofenac group.

2.5% of the patients in the tramadol group died, compared to 1.2% of the patients in the etoricoxib group.

However, due to the study’s design, it can’t be determined whether it was tramadol treatment that caused the higher rates of death.

If compared with other types of controlled substances, tramadol is a safer drug. Heroin is a Schedule I drug that carries a higher abuse potential and no acceptable medical use. OxyContin is a Schedule II drug that has a high risk of abuse but has an accepted medical use.

Increases Risk Of Addiction

Tramadol remains a dangerous drug that carries a risk for addiction if a person uses it:

For an extended period of time

In higher doses than what the doctor recommended

More frequently than what the doctor prescribed

For non-medical purposes

With other substances, such as alcohol, sedatives, or other painkillers

Main Usage

Just like other opioids, tramadol is used to treat chronic pain. Doctors prescribe the drug to people suffering from moderately severe pain, including pain after surgery and chronic conditions like arthritis. Patients can find it under one of its brand names, Ultram.

Treating Chronic Pain

An extended-release version of the drug is sometimes prescribed to patients with ongoing chronic pain. By taking this version of tramadol, patients can experience longer-lasting pain relief without taking the medication as frequently.

Tramadol binds to pain receptors, stopping pain signals. It’s often prescribed due to its less addictive properties than other painkillers. But due to its calming and euphoric effects, patients may develop an addiction to the drug, especially when it’s taken for a long time or when taken in larger doses than prescribed.

Doctors recommend a daily dose of 100-400 mg. The maximum daily dose should not exceed 400 mg. Normal-release forms may be given every 4-6 hours, and the extended-release forms should be given every 12-24 hours.

Past Substance Abuse

In almost 95% of cases, people who abuse the drug have a previous history of other substance abuse. 4 This means that people with an addiction history are more susceptible to developing an addiction.

Side Effects

Tramadol relieves pain by binding to opioid receptors in the brain and spinal cord. When a person takes a higher dose, they might experience a euphoric high that many abusers seek.

When a person takes the drug orally, tramadol converts into another compound. This compound is known as O-desmethyltramadol, which is a much more potent activator of opioid receptors. A person may get high on tramadol, even if it isn’t their intention.

Tramadol can also raise the levels of serotonin and norepinephrine in the brain, acting as an antidepressant drug. This mechanism is thought to be partially responsible for the drug’s ability to reduce depression and obsessive-compulsive symptoms in patients. It might also be one of the causes of why a person might develop an addiction to tramadol.

Short-Term Effects

The most common short-term effects of tramadol include:

Reduced Pain

Tramadol blocks pain signals in the brain, which results in a less intense pain for patients suffering from chronic pain.

Decreased Anxiety

Tramadol can also lead to feelings of relaxation and calm due to the way it changes brain chemistry. 

Elated Mood

The drug reduces depression and obsessive-compulsive symptoms in patients. As a result, patients may feel euphoric and happier. 

Potential Side Effects

Some possible side effects of tramadol include:





Loss of appetite

Difficulty concentrating


Muscle pain


Overdose Side Effects

Tramadol is a central nervous system depressant. As such, it can slow down the function of the lungs and heart. In some cases, people who take a larger dose than prescribed can stop breathing and overdose. The most common signs of a tramadol overdose include:





Respiratory distress

Abnormally low blood pressure

Slow heart rate


Muscle rigidity and muscle pain

Changes in pupil size

Weakened body

Purple nails and lips

Seizures most commonly happen when a person takes a large dosage. A large dosage is taking more than 400mg per day for an extended time.

Serotonin Syndrome

Serotonin syndrome is another potentially life-threatening side effect of tramadol abuse. Serotonin syndrome occurs when too much serotonin is produced or remains in the brain. It commonly happens when a patient takes tramadol together with antidepressants. Symptoms of serotonin syndrome include:


Rigid muscles

Lack of coordination





In Combination with Other Drugs

Tramadol is often taken in combination with other substances. This is known as polydrug use. People usually combine the drug with other substances to increase their high. Tramadol is commonly mixed with:



Other painkillers

Cold medicine

There are many health risks associated with taking tramadol with other drugs. Combining these drugs can result in respiratory depression. It can also increase the risk of seizure or overdose.

Long-Term Effects

If a person takes tramadol in higher doses for a long time, they may develop long-term side effects. The most common are:

Tolerance to the drug

Since tramadol changes the brain’s chemistry, there’s a risk of developing tolerance. The body gets used to the presence of the drug, so users will need larger doses to experience the same high.

Physical dependence

Extended usage of tramadol may also result in physical dependence. The body gets used to the presence of the drug and requires tramadol to function properly. Stopping the drug may result int he onset of withdrawal symptoms. 

Cognitive decline

Many people abusing tramadol may experience cognitive impairment and slow reaction times. They may find it more challenging to perform complex tasks in their daily life.

Withdrawal Symptoms

People with a physical dependence on tramadol will experience withdrawal symptoms if they reduce their dose too quickly or if they stop taking the drug altogether.

The most frequently experienced symptoms of tramadol withdrawal include: